Effect of methylprednisolone on experimental noncardiogenic pulmonary edema
Identifieur interne : 003790 ( Main/Exploration ); précédent : 003789; suivant : 003791Effect of methylprednisolone on experimental noncardiogenic pulmonary edema
Auteurs : S. L. Kopecky [États-Unis] ; W. C. Miller [États-Unis] ; K. M. Unger [États-Unis] ; B. L. Bradley [États-Unis] ; D. L. Rice [États-Unis]Source :
- Intensive Care Medicine [ 0342-4642 ] ; 1981-05-01.
English descriptors
- KwdEn :
- Teeft :
- Baseline, Beneficial effect, Body weight, Cardiac output, Corticosteroid, Dos, Edema, Embolism syndrome, Endothelial cells, Granulocyte aggregation, Intensive care, Kopecky, Lung water, Methylprednisolone, Mmhg, Monocrotaline, Monocrotaline model, Noncardiogenic, Oxygen content, Oxygen delivery, Oxygen gradient, Pharmacologic, Pharmacologic doses, Pulmonary edema, Pulmonary microcirculation, Significant difference, Surg, Surg gynecol obstet, Syndrome.
Abstract
Abstract: Methylprednisolone, 30 mg/kg body weight, was given to dogs 30 min and 4 h after injection of monocrotaline to produce noncardiogenic pulmonary edema. Control animals received monocrotaline but not corticosteroids. After 6 h the steroid-treated animals demonstrated significantly better gas exchange and significantly less pulmonary edema. A possible mechanism of this beneficial effect of steroids is inhibition of complement-leukocyte interactions which may mediate pulmonary microvascular injury. The results lend some support to the clinical practice of short-term pharmacologic doses of steroids in noncardiogenic pulmonary edema.
Url:
DOI: 10.1007/BF01738614
Affiliations:
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Box 20708, 77025, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Bradley, B L" sort="Bradley, B L" uniqKey="Bradley B" first="B. L." last="Bradley">B. L. Bradley</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pulmonary Division, University of Texas Medical School, P.O. Box 20708, 77025, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rice, D L" sort="Rice, D L" uniqKey="Rice D" first="D. L." last="Rice">D. L. Rice</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pulmonary Division, University of Texas Medical School, P.O. Box 20708, 77025, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Intensive Care Medicine</title><title level="j" type="abbrev">Intensive Care Med</title><idno type="ISSN">0342-4642</idno><idno type="eISSN">1432-1238</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1981-05-01">1981-05-01</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="121">121</biblScope><biblScope unit="page" to="124">124</biblScope></imprint><idno type="ISSN">0342-4642</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0342-4642</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult respiratory distress syndrome</term><term>Glucocorticoid</term><term>Lung water</term><term>Monocrotaline</term><term>Posttraumatic pulmonary insufficiency</term><term>Pulmonary circulation</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Baseline</term><term>Beneficial effect</term><term>Body weight</term><term>Cardiac output</term><term>Corticosteroid</term><term>Dos</term><term>Edema</term><term>Embolism syndrome</term><term>Endothelial cells</term><term>Granulocyte aggregation</term><term>Intensive care</term><term>Kopecky</term><term>Lung water</term><term>Methylprednisolone</term><term>Mmhg</term><term>Monocrotaline</term><term>Monocrotaline model</term><term>Noncardiogenic</term><term>Oxygen content</term><term>Oxygen delivery</term><term>Oxygen gradient</term><term>Pharmacologic</term><term>Pharmacologic doses</term><term>Pulmonary edema</term><term>Pulmonary microcirculation</term><term>Significant difference</term><term>Surg</term><term>Surg gynecol obstet</term><term>Syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Methylprednisolone, 30 mg/kg body weight, was given to dogs 30 min and 4 h after injection of monocrotaline to produce noncardiogenic pulmonary edema. Control animals received monocrotaline but not corticosteroids. After 6 h the steroid-treated animals demonstrated significantly better gas exchange and significantly less pulmonary edema. A possible mechanism of this beneficial effect of steroids is inhibition of complement-leukocyte interactions which may mediate pulmonary microvascular injury. The results lend some support to the clinical practice of short-term pharmacologic doses of steroids in noncardiogenic pulmonary edema.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Kopecky, S L" sort="Kopecky, S L" uniqKey="Kopecky S" first="S. L." last="Kopecky">S. L. Kopecky</name></region><name sortKey="Bradley, B L" sort="Bradley, B L" uniqKey="Bradley B" first="B. L." last="Bradley">B. L. Bradley</name><name sortKey="Miller, W C" sort="Miller, W C" uniqKey="Miller W" first="W. C." last="Miller">W. C. Miller</name><name sortKey="Rice, D L" sort="Rice, D L" uniqKey="Rice D" first="D. L." last="Rice">D. L. Rice</name><name sortKey="Unger, K M" sort="Unger, K M" uniqKey="Unger K" first="K. M." last="Unger">K. M. Unger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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